p16INK4a in cellular senescence
نویسندگان
چکیده
منابع مشابه
p16INK4a in cellular senescence
senescence is the activation of the INK4/ARF locus, which is epigenetically regulated and under tight control of the Polycomb group (PcG) Trithorax group (TrxG) proteins [1]. In proliferating cells, the locus is silenced by Polycomb repressive complexes (PRCs), and the chromatin is enriched in H3K27me3 [2]. Upon senescence triggers, PRCs are displaced and the repressive H3K27me3 mark is removed...
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ژورنال
عنوان ژورنال: Aging
سال: 2013
ISSN: 1945-4589
DOI: 10.18632/aging.100592